FV replication more closely resembles the Hepadnaviridae, which are another family of reverse transcriptase encoding viruses. FV is characterized by an immature looking core with an electron lucent center with glycoprotein spikes on the surface. Some of the main differences are that FV buds from the endoplasmic reticulum instead of the plasma membrane this difference gives FV a unique morphology. Most of the differences between the spumaviruses and the other retroviruses come from the life cycle. This subspecies has a natural habitat in Kenya and thus was most likely the origin of this SFV variant, and the virus was probably acquired as a zoonotic infection. When looking at the origin of the human FV, sequence comparisons showed that from four different species of chimpanzees, SFVcpz(hu) was most closely related to the Eastern chimpanzee. These results indicated that SFVcpz(hu) is likely a variant of SFV and not a unique isolate. In addition, phylogenetic analysis showed that the pol regions of the two genomes shared 89–92% of their nucleotides and 95–97% of the amino acids are identical between the human virus and various SFV strains. The sequencing showed that there are 86–95% identical amino acids between the SFV and the one isolated from the Kenyan patient. The debate came to an end in 1994 when the virus was cloned and sequenced. In another report, however, a different group of researchers claimed that SFVcpz(hu) was not a distinct type of FV but rather a variant strain of chimpanzee FV. Not long after this, a group of researchers concluded that it was a distinct type of FV and most closely related to SFV types 6 and 7, both of which were isolated from chimpanzees. The SFV came from its similarity to simian foamy virus (SFV). The agent was termed a human FV because of its origin, and named SFVcpz(hu) as the prototypic laboratory strain. In 1971, a viral agent with FV-like characteristics was isolated from lymphoblastoid cells released from a human nasopharyngeal carcinoma (NPC) from a Kenyan patient. It was not until several years later that humans entered the scene. Not too long after this, it was isolated from a wide variety of New and Old World monkeys, cats, and cows. The first isolate of the “foamy viral agent” was in 1955. It was found as a contaminant in primary monkey kidney cultures. The first description of foamy virus (FV) was in 1954. įoamy virus in humans occurs only as a result of zoonotic infection. The foamy viruses derive their name from the characteristic ‘foamy’ appearance of the cytopathic effect (CPE) induced in the cells. The spumaviruses are complex and significantly different from the other six genera of retroviruses in several ways. Human foamy virus ( HFV) is a retrovirus and specifically belongs to the genus Spumavirus.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |